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  Indian J Med Microbiol
 

Figure 4: Histological changes in liver tissues in different study groups. The DPFAE prophylactic groups (group 2) showed normal hepatocytic structure with mildly congested portal vein as in A (scale bar = 50 μm, H&E ×200). The DOX-treated group showed marked sinusoidal dilation with the tigroid pattern and hepatocytic degenerative changes as in B (scale bar = 50 μm, H&E ×200) and markedly dilated central vein with a rim of hepatocytes exhibiting ballooning degeneration as in C, note the black arrows (scale bar = 20 μm, H&E ×400). The DPFAE (0.75 mg/kg bwt) protected group showed mildly congested central vein and blood sinusoids with apparently normal hepatocytes as in D (scale bar = 20 μm, H&E ×400) and normal hepatocytes with an area of focal spotty necrosis in group 5 as in E, note the black arrow (scale bar = 50 μm, H&E ×200).

Figure 4: Histological changes in liver tissues in different study groups. The DPFAE prophylactic groups (group 2) showed normal hepatocytic structure with mildly congested portal vein as in A (scale bar = 50 μm, H&E ×200). The DOX-treated group showed marked sinusoidal dilation with the tigroid pattern and hepatocytic degenerative changes as in B (scale bar = 50 μm, H&E ×200) and markedly dilated central vein with a rim of hepatocytes exhibiting ballooning degeneration as in C, note the black arrows (scale bar = 20 μm, H&E ×400). The DPFAE (0.75 mg/kg bwt) protected group showed mildly congested central vein and blood sinusoids with apparently normal hepatocytes as in D (scale bar = 20 μm, H&E ×400) and normal hepatocytes with an area of focal spotty necrosis in group 5 as in E, note the black arrow (scale bar = 50 μm, H&E ×200).