Figure 6: Pathological study of tumor specimens from A549 xenograft mice. (A) Hematoxylin and eosin staining of the xenograft tumor. The specimens were composed of epithelial cell tumors arranged in an acinar pattern. Magnification, × 400; scale bars, 10 μm. (B) Immunohistochemical staining of xenograft mouse specimens treated as indicated. Cleaved PARP and cleaved caspase-3 signaling were strongly detected in the specimens from xenograft mice treated with 15 mg/kg THC or 40 mg/kg CBN. Phosphorylated AKT was barely expressed in the specimens from xenograft mice treated with 15 mg/kg THC or 40 mg/kg CBN compared to the specimens from the control mice. Magnification ×400; scale bars, 20 μm.