Figure 5: Effects of THC and CBN on tumor growth in A549 xenograft mice. (A) Experimental timeline schematic for the animal experiment. (B) The average body weights of nude mice after tumor induction. (C) Tumors of xenograft mice after treatment with (1) control, (2) 20 mg/kg CBN, (3) 40 mg/kg CBN, and (4) 15 mg/kg THC for 20 d. (D) Tumor growth curves for control, 20 mg/kg CBN-, 40 mg/kg CBN- and 15 mg/kg THC-treated mice. The tumors from A549 xenograft mice treated with 15 mg/kg THC and 40 mg/kg CBN were significantly decreased compared with those of control mice on day 20 (ANOVA, P=0.036 for 15 mg/kg THC and **P=0.042 for 40 mg/kg CBN). (E) Tumor progression curve indicating the percentage of mice with tumor volumes less than 300 mm3. THC at 15 mg/kg and CBN at 40 mg/kg significantly inhibit tumor growth in A549 xenograft mice compared to the control mice (log-rank test, P=0.012 for 15 mg/kg THC and **P=0.042 for 40 mg/kg CBN).