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  Indian J Med Microbiol
 

Figure 2: Effect of phytosomal curcumin on clinical symptoms associated with collagen-induced arthritis (CIA). Rats were immunized with C II and IFA and then administered with phytosomal curcumin or vehicle starting from day 0 and 7 post-immunization. Rats were monitored for signs of CIA, and the results are presented as (A) clinical scores, (C) paw volume, (E) percent of inflammation and (G) percent of improvement. (B), (D), (F), and (H) show total area under curve (AUC) for clinical scores, paw volume, percent of inflammation, and percent of improvement, respectively. Data are presented as mean±SD and analyzed by one-way ANOVA followed by Tukey post hoc test. *P<0.05, **P<0.01, and ***P<0.001 versus the CIA group. #P<0.05, ##P<0.01, and ###P<0.001 versus the control group. Ctrl: healthy rats without CIA induction; CIA: CIA was induced and treated with vehicle; IDM: CIA was induced and treated with indomethacin; Phyto-cur-0: CIA was induced and treated with phytosomal curcumin from day 0 and Phyto-cur-7: CIA was induced and treated with phytosomal curcumin from day 7.

Figure 2: Effect of phytosomal curcumin on clinical symptoms associated with collagen-induced arthritis (CIA). Rats were immunized with C II and IFA and then administered with phytosomal curcumin or vehicle starting from day 0 and 7 post-immunization. Rats were monitored for signs of CIA, and the results are presented as (A) clinical scores, (C) paw volume, (E) percent of inflammation and (G) percent of improvement. (B), (D), (F), and (H) show total area under curve (AUC) for clinical scores, paw volume, percent of inflammation, and percent of improvement, respectively. Data are presented as mean±SD and analyzed by one-way ANOVA followed by Tukey <i>post hoc</i> test. <sup>*</sup><i>P</i><0.05, <i>**P</i><0.01, and <sup>***</sup><i>P</i><0.001 versus the CIA group. <sup>#</sup><i>P</i><0.05, <sup>##</sup><i>P</i><0.01, and <sup>###</sup><i>P</i><0.001 versus the control group. Ctrl: healthy rats without CIA induction; CIA: CIA was induced and treated with vehicle; IDM: CIA was induced and treated with indomethacin; Phyto-cur-0: CIA was induced and treated with phytosomal curcumin from day 0 and Phyto-cur-7: CIA was induced and treated with phytosomal curcumin from day 7.