Figure 1: Apoptosis via the intrinsic and extrinsic pathways induced by deoxyelephantopin (DET). (A) Representative images of protein array. (B) Fold change of apoptosis-related proteins after DET treatment. 1- Caspase-3, 2- p53, 3- p21, 4- XIAP, 5- FAS, 6- DR4, 7- DR5, 8- Survivin, 9- IGF-1R and 10- IGFBP-5. (C) Apoptosis-related protein expressions of DET-treated cells at 6-24 h. The numbers above each band represent mean fold change of three separate experiments. (D) Mitochondrial membrane potential detected by mito-ID staining. Data are expressed as mean ± SE from three separate experiments. *P<0.05 compared to the control.