ORIGINAL ARTICLE
Year : 2023 | Volume
: 13 | Issue : 2 | Page : 70--79
Salidroside attenuates oxygen and glucose deprivation-induced neuronal injury by inhibiting ferroptosis
Ying-Zhi Li1, Ai-Ping Wu1, Dan-Dan Wang1, Pan-Pan Yang1, Bin Sheng2
1 Department of Rehabilitation Medicine, Zhejiang Hospital, Hangzhou 310007, Zhejiang, China
2 Department of Emergency Medicine, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang, China
Correspondence Address:
Bin Sheng
Department of Emergency Medicine, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang
China
Objective: To evaluate the effect of salidroside on oxygen and glucose deprivation (OGD)-treated NT2 cells and its underlying mechanisms of action.
Methods: Retinoic acid was used to induce the differentiation of NT2 cells into neurons. The effects of salidroside on survival, apoptosis, inflammatory response, and oxidative stress of neurons undergoing OGD were evaluated. Using precursor cells as controls, the effect of salidroside on the differentiation progression of OGD-treated cells was evaluated. In addition, the effect of erastin, a ferroptosis inducer, on NT2 cells was examined to investigate the underlying mechanisms of neuroprotective action of salidroside.
Results: Salidroside alleviated the effects of OGD on neuronal survival, apoptosis, inflammation, and oxidative stress, and promoted NT2 cell differentiation. Moreover, salidroside prevented ferroptosis of OGD-treated cells, which was abolished following erastin treatment, indicating that ferroptosis mediated the regulatory pathway of salidroside.
Conclusions: Salidroside attenuates OGD-induced neuronal injury by inhibiting ferroptosis and promotes neuronal differentiation.
How to cite this article:
Li YZ, Wu AP, Wang DD, Yang PP, Sheng B. Salidroside attenuates oxygen and glucose deprivation-induced neuronal injury by inhibiting ferroptosis.Asian Pac J Trop Biomed 2023;13:70-79
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How to cite this URL:
Li YZ, Wu AP, Wang DD, Yang PP, Sheng B. Salidroside attenuates oxygen and glucose deprivation-induced neuronal injury by inhibiting ferroptosis. Asian Pac J Trop Biomed [serial online] 2023 [cited 2023 Mar 24 ];13:70-79
Available from: https://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=2;spage=70;epage=79;aulast=Li;type=0 |
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