| ORIGINAL ARTICLE |
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| Year : 2023 | Volume
: 13
| Issue : 4 | Page : 156-164 |
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Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats
Gayatri Khuntia1, Jeevan Ranjan Dash1, Biswadeep Jena2, Uma Kanta Mishra3, Subash Chandra Parija1
1 Department of Pharmacology and Toxicology, College of Veterinary Sciences and Animal Husbandry, OUAT, Bhubaneswar, India
2 Department of Veterinary Surgery and Radiology, College of Veterinary Sciences and Animal Husbandry, OUAT, Bhubaneswar, India
3 Department of Veterinary Anatomy and Histology, College of Veterinary Sciences and Animal Husbandry, OUAT, Bhubaneswar, India
Correspondence Address:
Jeevan Ranjan Dash
Department of Pharmacology and Toxicology, College of Veterinary Sciences and Animal Husbandry, OUAT, Bhubaneswar
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/2221-1691.374232
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Objective: To explore the cardioprotective effect of hesperidin against arsenic trioxide-induced cardiac toxicity in rats.
Methods: Cardiac toxicity was induced by oral administration of 4 mg/kg arsenic trioxide for 30 days. Hematological, biochemical, electrocardiography, echocardiography, and histopathological examinations were performed.
Results: Hesperidin decreased the neutrophil-to-lymphocyte ratio, calcium, creatine kinase-myoglobin binding, lactate dehydrogenase, IL-6, and lipid peroxidation, as well as increased sodium and potassium concentration and superoxide dismutase and catalase activity in arsenic trioxide-intoxicated rats. Moreover, it reduced peak systolic velocity and end-diastolic velocity while increasing heart rate. Arsenic trioxide-induced histopathological damage to cardiac tissue was prominently alleviated by hesperidin treatment.
Conclusions: Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats. Therefore, it can be further explored as a cardioprotective agent.
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