| ORIGINAL ARTICLE |
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| Year : 2023 | Volume
: 13
| Issue : 4 | Page : 148-155 |
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Cardioprotective effects of Pinus eldarica bark extract on adrenaline-induced myocardial infarction in rats
Leila Safaeian1, Zahra Haghighatian2, Behzad Zolfaghari3, Mahdi Amindeldar1
1 Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Pathology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
Correspondence Address:
Leila Safaeian
Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan
Iran
 Source of Support: This study was financially supported by Vice-Chancellery for Research and Technology of Isfahan University of Medical Sciences (research projects No. 3400680), Conflict of Interest: None
DOI: 10.4103/2221-1691.374231
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Objective: To investigate the effect of Pinus eldarica bark extract on adrenaline-induced myocardial infarction.
Methods: Hydroalcoholic extract was prepared using maceration method and its total phenolic content was determined using the Folin-ciocalteu method. Pretreatment was done by oral administration of 100, 200, and 400 mg/kg Pinus eldarica bark extract for 16 days in male Wistar rats. Injection of adrenaline (2 mg/kg, s.c.) was performed on the 15th and 16th days for induction of myocardial infarction. Lead II EEG was recorded. Serum cardiac marker enzymes and antioxidative parameters were evaluated and a histopathological examination of heart tissues was performed.
Results: Pretreatment with Pinus eldarica bark extract especially at its high doses significantly lowered the ST-segment elevation, improved heart rate, and decreased RR interval in ECG pattern of rats with adrenaline-induced myocardial infarction. It declined serum markers of heart damage including aspartate aminotransferase, lactate dehydrogenase, and creatine phosphokinase-MB, and also decreased lipid peroxidation marker, and heart weight while raising total antioxidant capacity and considerably improved histopathological alterations of the heart induced by adrenaline.
Conclusions: Pinus eldarica bark extract shows beneficial cardioprotective and antioxidant effects against adrenaline-induced myocardial infarction. It can be further explored as a potential treatment for myocardial infarction.
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