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Year : 2023  |  Volume : 13  |  Issue : 2  |  Page : 70-79

Salidroside attenuates oxygen and glucose deprivation-induced neuronal injury by inhibiting ferroptosis

1 Department of Rehabilitation Medicine, Zhejiang Hospital, Hangzhou 310007, Zhejiang, China
2 Department of Emergency Medicine, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang, China

Correspondence Address:
Bin Sheng
Department of Emergency Medicine, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang
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Source of Support: This study was supported by the Zhejiang Traditional Chinese Medicine Science and Technology Plan Project (2021ZB027, 2023ZL267) and Zhejiang Medical and Health Platform Project of China (2019KY002, 2019RC092), Conflict of Interest: None

DOI: 10.4103/2221-1691.369611

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Objective: To evaluate the effect of salidroside on oxygen and glucose deprivation (OGD)-treated NT2 cells and its underlying mechanisms of action. Methods: Retinoic acid was used to induce the differentiation of NT2 cells into neurons. The effects of salidroside on survival, apoptosis, inflammatory response, and oxidative stress of neurons undergoing OGD were evaluated. Using precursor cells as controls, the effect of salidroside on the differentiation progression of OGD-treated cells was evaluated. In addition, the effect of erastin, a ferroptosis inducer, on NT2 cells was examined to investigate the underlying mechanisms of neuroprotective action of salidroside. Results: Salidroside alleviated the effects of OGD on neuronal survival, apoptosis, inflammation, and oxidative stress, and promoted NT2 cell differentiation. Moreover, salidroside prevented ferroptosis of OGD-treated cells, which was abolished following erastin treatment, indicating that ferroptosis mediated the regulatory pathway of salidroside. Conclusions: Salidroside attenuates OGD-induced neuronal injury by inhibiting ferroptosis and promotes neuronal differentiation.

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