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Year : 2023  |  Volume : 13  |  Issue : 1  |  Page : 9-16

Quercetin modulates ovarian autophagy–related molecules and stereological parameters in a rat model of PCOS

1 Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2 Physiology, Endocrine and Metabolism Research Center, Shiraz University of Medical Science, Shiraz, Iran
3 Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
4 Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Correspondence Address:
Fatemeh Zal
Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz
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Source of Support: This work was supported by the Shiraz University of Medical Sciences (grant number: 10774), Conflict of Interest: None

DOI: 10.4103/2221-1691.367686

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Objective: To examine the effect of quercetin on stereological parameters and autophagy-related genes in ovaries of polycystic ovary syndrome (PCOS) rats. Methods: Fifty female Sprague-Dawley rats were randomly divided into five groups: the control group, the ethanol group, the quercetin group (15 mg/kg/day), the PCOS group, as well as the PCOS + quercetin group. After the induction of PCOS, quercetin was administered orally for 30 days. Histological, stereological and real-time PCR analyses were carried out to evaluate the effect of quercetin on PCOS rats. Results: Stereological analysis revealed that quercetin significantly increased the number of ovarian follicles and the volume of corpus luteum and induced a significant decrease in atretic follicles in comparison to the PCOS group. In addition, quercetin markedly increased mTOR gene expression while decreasing Beclin-1 and LC3 gene expression. Conclusions: Quercetin strongly modulates the expression of ovarian autophagy-related genes and stereological parameters in PCOS rats. Therefore, it can be considered as an ameliorative component for ovarian follicular impairments.

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