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ORIGINAL ARTICLE
Year : 2022  |  Volume : 12  |  Issue : 5  |  Page : 197-206

Humulus japonicus extract alleviates oxidative stress and apoptosis in 6-hydroxydopamine-induced PC12 cells


1 Department of Health Management, Jeonju University, Jeonju 55069, Korea; Department of Life Sciences, Yuncheng University, Yuncheng, Shanxi Province 044000, PR China
2 Research Institute, Ato Q&A Co, LTD, Cheonjam-ro, Wansan-gu; Institute of Health & Science, Jeonju University, Jeonju 55069, Korea
3 Research Institute, Ato Q&A Co, LTD, Cheonjam-ro, Wansan-gu, Jeonju 55069, Korea
4 Department of Health Management, Jeonju University, Jeonju 55069, Korea
5 Department of Health Management, Jeonju University; Research Institute, Ato Q&A Co, LTD, Cheonjam-ro, Wansan-gu, Jeonju 55069, Korea

Correspondence Address:
Seon Il Jang
Department of Health Management, Jeonju University; Research Institute, Ato Q&A Co, LTD, Cheonjam-ro, Wansan-gu, Jeonju 55069
Korea
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Source of Support: This study was financially supported by the Ministry of Small and Medium Enterprise and Startups (MSS), Korea, under the Social Economy Innovation Growth Project (R&D) (Project number P0013037), Conflict of Interest: None


DOI: 10.4103/2221-1691.343387

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Objective: To explore the possible neuroprotective activities of Humulus japonicus extract against Parkinson’s disease (PD) in a cellular model. Methods: PD was modeled in PC12 cells using 6-hydroxydopamine (6-OHDA). The cell activity, intracellular levels of reactive oxygen species (ROS), anti-oxidative and anti-apoptotic effects, and other related indicators and related signaling pathways were evaluated to elucidate the neuroprotective effects of Humulus japonicus extract. Results: Humulus japonicus extract exhibited anti-oxidative and anti-apoptotic effects in 6-OHDA-stimulated PC12 cells. It also reduced oxidative stress-induced ROS accumulation; upregulated antioxidant enzymes, such as glutathione, catalase, heme oxidase-1, and 8-oxguanine glycosylase 1; promoted cell survival by decreasing BAX and increasing Bcl-2 and sirtuin 1 expression via the MAPK and/or Nrf2 signaling pathways. Conclusions: Humulus japonicus extract has antioxidative and anti-apoptotic effects and could be developed as a promising candidate for preventing and treating oxidative stress-related neurodegenerative diseases.


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