Impact Factor 2020 : 1.545 (@Clarivate Analytics)
  • Users Online: 205
  • Print this page
  • Email this page
Year : 2021  |  Volume : 11  |  Issue : 11  |  Page : 491-499

Anti-inflammatory and antipyretic potential of Arbutus andrachne L. methanolic leaf extract in rats

1 Department of Biological Sciences, Faculty of Science, The University of Jordan, 11942 Amman, Jordan
2 Department of Anatomy and Histology, Faculty of Medicine, The University of Jordan, 11942 Amman, Jordan

Correspondence Address:
Sahar M Jaffal
Department of Biological Sciences, Faculty of Science, The University of Jordan, 11942 Amman
Login to access the Email id

Source of Support: This project was funded by the Deanship of Scientific Research, The University of Jordan (235/2020/19), Conflict of Interest: None

DOI: 10.4103/2221-1691.328056

Get Permissions

Objective: To explore the anti-inflammatory and antipyretic effects of methanolic leaf extract from Arbutus andrachne and its mechanism of action. Methods: Paw edema was induced by intraplantar ( injection of λ-carrageenan (1% w/v, 100 μL/paw) while pyrexia was evoked by intraperitoneal (i.p.) injection of 20% baker’s yeast (20 mL/kg body wt) in male Wistar rats. The anti-inflammatory and antipyretic effects of Arbutus andrachne methanolic leaf extract were explored by injecting rats with different doses of the plant extract (150, 300, and 600 mg/kg body wt, i.p.). Selective antagonists for transient receptor potential vanilloid-1 (TRPV1), cannabinoid receptor 1 (CB1), and alpha-2 adrenergic receptor (a2-AR) were used to unravel the extracts’ mechanism of action. Blood samples were collected from the heart of rats to measure the levels of interleukin-6 (IL-6) and prostaglandin E2 (PGE2) by enzyme-linked immunosorbent assay. Results: The extract exhibited potent anti-inflammatory activity by decreasing paw thickness and IL-6 levels. In addition, yeast-evoked pyrexia was attenuated by the extract treatment via TRPV1 and CB1 receptors and a reduction in PGE2 levels. No significant effects were found for a2-AR. Moreover, the rats that received the plant extract demonstrated similar responses to the positive control group. Conclusions: Arbutus andrachne can be a good candidate for treating inflammation and pyrexia and should be further investigated.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded138    
    Comments [Add]    

Recommend this journal