| ORIGINAL ARTICLE |
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| Year : 2019 | Volume
: 9
| Issue : 5 | Page : 217-221 |
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Neuropharmacological evaluation of methanolic extract of Costus speciosus Linn. rhizome in Swiss albino mice
Umay Chen1, Md. Saddam Hussain2, Tanoy Mazumder2, SM Naim Uddin3, Sujan Banik2
1 Department of Pharmacy, University of Chittagong, Chittagong-4331; Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
2 Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
3 Department of Pharmacy, University of Chittagong, Chittagong-4331, Bangladesh
Correspondence Address:
Assistant Professor Sujan Banik
Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814
Bangladesh
 Source of Support: None, Conflict of Interest: None  | 5 |
DOI: 10.4103/2221-1691.259002
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Objective: To evaluate the neuropharmacological properties of Costus speciosus (C. speciosus) rhizome using different experimental mouse models.
Methods: The anxiolytic effect was investigated by hole-board test, elevated plus maze and light/dark test, while central nervous system (CNS) depressant effect was evaluated by thiopental sodium-induced sleep test. Finally, antidepressant effect was evaluated by forced swimming test and tail suspension test.
Results: In both elevated plus maze and hole board test, 400 mg/kg C. speciosus showed more significant CNS depressant effect than 1 mg/kg diazepam. Both 200 mg/kg and 400 mg/kg C. speciosus extract produced a significant dose-dependent decrease in onset of sleep. In forced swimming test, C. speciosus rhizome showed a decrease in duration of immobility in a dose-dependent manner. Imipramine (10 mg/kg) and C. speciosus extract at 400 mg/kg dose exhibited a significant reduction in duration of immobility in tail suspension test which provided additional evidence of antidepressant effect of C. speciosus rhizome.
Conclusions: Our study indicates that C. speciosus rhizome possesses CNS depressant, anxiolytic and antidepressant-like activities. Further studies are warranted determine the exact phytoconstituents and mechanism of action responsible for the neuropharmacological effect. |
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