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Significance of IL-1Ra and IL-6 gene variants in Turkish patients with Crimean-Congo hemorrhagic fever
Umut Safiye Say Coskun1, Ayse Feyda Nursal2, Ferdi Gunes3, Aydın Rustemoglu4, Abdullah Yayli5, Nevin Karakus4, Huseyin Sener Barut6, Serbulent Yigit4
1 Tokat Gaziosmanpasa University, Medicine Faculty, Department of Medical Microbiology, Tokat, Turkey
2 Hitit University, Medicine Faculty, Department of Medical Genetics, Corum, Turkey
3 Obstetrics and Pediatrics Hospital, Clinic of Infectious Disease, Aydin, Turkey
4 Tokat Gaziosmanpasa University, Medicine Faculty, Department of Medical Biology, Tokat, Turkey
5 Tokat Gaziosmanpasa University, Medicine Faculty, Microbiology Laboratory, Tokat, Turkey
6 Tokat Gaziosmanpasa University, Medicine Faculty, Department of Infectious Disease, Tokat, Turkey
Correspondence Address:
Umut Safiye Say Coskun
Tokat Gaziosmanpasa University Faculty of Medicine, Department of Medical Microbiology, Tokat
Turkey
 Source of Support: None, Conflict of Interest: None  | 2 |
DOI: 10.4103/2221-1691.250864
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Objective: To investigate the association between IL-1Ra variable number of tandem repeat (rs2234663), IL-6 -597GA (rs1800797), IL-6 -572GC (rs1800796) and the risk of Crimean-Congo hemorrhagic fever (CCHF) in the Turkish patients. Methods: This study included 50 patients infected with CCHF and 50 healthy controls. These variants were genotyped using polymerase chain reaction and/or restriction fragment length polymorphism method. Results: The distribution of the IL-6 -572GC genotypes and alleles varied significantly between the patients and the controls. The subjects carrying IL-6 -572GC GG genotype and G allele had increased risk of developing CCHF compared to the control group (P=0.006, P=0.014, respectively). IL-6 -572GC GC genotype was higher in the controls than the patients (P=0.006). For the triple genotype combinations, the 1/2-GC-GG genotype combination was detected more frequently in the control group than CCHF patients (P=0.016). IL-6 (-572/-597) GG-GG genotype was significantly higher in the patient group (P=0.015), while the GC-GG genotype was significantly lower in the patient group (P=0.005). Additionally, the G-G haplotype was significantly higher in the patient group (P=0.042), whereas C-G was found to be significantly lower in the patients than the control group (P=0.037). Conclusions: The results of this study suggest the IL-6 -572GC variant might be genetic markers of sensitivity to CCHF in the Turkish population and may facilitate greater protection against the disease.
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