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BASIC RESEARCH
Year : 2018  |  Volume : 8  |  Issue : 7  |  Page : 371-376

Influence of different cultivars of Phoenix dactylifera L-date fruits on blood clotting and wound healing


1 Division of Immunology, Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Muscat, Oman
2 Research Center, Dhofar University; Department of Mathematics and Sciences, College of Arts and Applied Sciences, Dhofar University, Salalah, Oman
3 Primary Health Corporation, Hamad Medical Corporation, PO.Box20980, Doha, State of Qatar

Correspondence Address:
S S Hasson
Department of Microbiology & Immunology, Room 12, College of Medicine & Health Sciences, Sultan Qaboos University, P.O. Box 35, Al-Khod, Postal Code 123
Oman
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2221-1691.237081

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Objective: To investigate different types of dates and medical properties of influencing blood clotting and wound healing in an animal model. Methods: Three different cultivars of dates (Ajwa, Khalas, and Fardh) were examined in-vivo, for blood clotting and wound healing using CD1 mice of both sexes. Study of toxicity to animals was performed accordingly prior to further investigations. The ethanolic extracts were given orally to animals as a constituent in their daily water. Blood samples were obtained from the mice inferior vena cava to carry out the prothrombin time (PT) assay using the manual method and confirmed using a semi-automated machine. The bleeding time (BT) assay was performed using the cutting technique. In the wound healing analysis, a small cut (5-10 mm) in the skin overlying the thigh was conducted in all mice under anesthesia. The diameter of the cut and healing status were measured on a daily basis throughout the time of the experiment using a roller. Results: Ajwa was able to elevate both PT and BT (P<0.05), significantly in a time-dependent manner followed by Khalas date (P<0.05). The results of PT and BT of Fardh date were found to be very close to those of the control group (P<0.05). Despite its activity as an anticoagulant, Khalas date showed a potential property to enhance wound healing in contrast to other dates and the control groups in this study. Conclusions: Omani Khalas date fruit has both antithrombotic as well as wound healing properties. The results open a new gate with these fruits for exploring the potential component(s) that may play an important role in antithrombotic as well as wound healing process.


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